Down‐regulation of mitochondrial mRNAs in the mdx mouse model for Duchenne muscular dystrophy

FEBS Letters

Dechesne, C.A¹  Gannoun-Zaki, L¹  Fournier-Bidoz, S¹  Chambon, C¹  Le Cam, G¹  Millasseau, Ph²  Léger, J.J¹ 

[1] INSERM Unité 300, Faculté de Pharmacie, 15 Avenue Charles Flahaut, 34060 Montpellier Cedex 01, France;Centre d'Etude du Polymorphisme Humain, 75010 Paris, France

关键词: Dystrophin;    Gene expression regulation;    Mitochondrial RNA;    DMD;    Duchenne muscular dystrophy;    GAPDH;    glyceraldehyde-3-phosphate dehydrogenase;    PCR;    polymerase chain reaction;    ND;    NADH dehydrogenase;    CO;    cytochrome c oxidase;    Cyt b;    cytochrome b;   

DOI  :  10.1016/0014-5793(95)01225-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In our search for genes up- or down-regulated genes in the mdx mouse model for Duchenne muscular dystrophy, we isolated a down-regulated mitochondrial DNA clone. In addition to this clone, all protein-coding mitochondrial genes tested had tissue-specific and age independent down-regulated expression. This implied mechanisms at the RNA level since no change in the mitochondrial DNA contents were detected. Cytochrome c oxidase activity showed the same range of down-regulated expression. These data provide a molecular basis for energetic metabolism modifications in mdx mice.

【 授权许可】

Unknown