期刊论文详细信息
FEBS Letters | |
Down‐regulation of mitochondrial mRNAs in the mdx mouse model for Duchenne muscular dystrophy | |
Dechesne, C.A1  Gannoun-Zaki, L1  Fournier-Bidoz, S1  Chambon, C1  Le Cam, G1  Millasseau, Ph2  Léger, J.J1  | |
[1] INSERM Unité 300, Faculté de Pharmacie, 15 Avenue Charles Flahaut, 34060 Montpellier Cedex 01, France;Centre d'Etude du Polymorphisme Humain, 75010 Paris, France | |
关键词: Dystrophin; Gene expression regulation; Mitochondrial RNA; DMD; Duchenne muscular dystrophy; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; PCR; polymerase chain reaction; ND; NADH dehydrogenase; CO; cytochrome c oxidase; Cyt b; cytochrome b; | |
DOI : 10.1016/0014-5793(95)01225-4 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
In our search for genes up- or down-regulated genes in the mdx mouse model for Duchenne muscular dystrophy, we isolated a down-regulated mitochondrial DNA clone. In addition to this clone, all protein-coding mitochondrial genes tested had tissue-specific and age independent down-regulated expression. This implied mechanisms at the RNA level since no change in the mitochondrial DNA contents were detected. Cytochrome c oxidase activity showed the same range of down-regulated expression. These data provide a molecular basis for energetic metabolism modifications in mdx mice.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020301927ZK.pdf | 869KB | download |