Fast solute release from photosensitive liposomes: an alternative to ‘caged’ reagents for use in biological systems

FEBS Letters

Bisby, Roger H.¹  Johnson, Steven A.¹  Mitchell, Andrew C.¹  Morgan, Christopher G.¹ 

[1] Department of Biological Sciences, University of Salford, Salford M5 4WT, UK

关键词: Liposome;    Photochromism;    Photolysis;    Laser;    Solute release;   

DOI  :  10.1016/0014-5793(95)01193-I

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The kinetics of release of soluble marker trapped in liposomes of gel phase phospholipid containing a photoisomerisable phospholipid analogue have been investigated. Marker release is triggered by UV laser flash photolysis at 355 nm. A markedly temperature-dependent release rate is seen, and above 25°C millisecond release kinetics can be achieved. These results suggest that such liposomes might find application as an alternative to conventional ‘caged’ reagents for photo-triggered reagent release in biological research.

【 授权许可】

Unknown