期刊论文详细信息
FEBS Letters | |
Expression of cytochrome P450 CYP1B1 in breast cancer | |
Melvin, William T.3  Burke, M.Danny4  Greenlee, William F.1  Murray, Graeme I.2  McKay, Judith A.2  Ewen, Stanley W.B.2  Marcus, Craig B.1  Ah-See, A.K.5  | |
[1] Department of Pharmacology and Toxicology, Purdue University, West Lafayette, IN 47907-1334, USA;Department of Pathology, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Molecular and Cell Biology, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Biomedical Sciences, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Surgery, University of Aberdeen, Aberdeen AB9 2ZD, UK | |
关键词: Breast; Cancer; Cytochrome P450; Neoplasm; P450; cytochrome P450; RT-PCR; reverse transcriptasepolymerase chain reaction; | |
DOI : 10.1016/0014-5793(95)01126-Y | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.
【 授权许可】
Unknown
【 预 览 】
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RO201912020301824ZK.pdf | 293KB | download |