Expression of cytochrome P450 CYP1B1 in breast cancer

FEBS Letters

Melvin, William T.³  Burke, M.Danny⁴  Greenlee, William F.¹  Murray, Graeme I.²  McKay, Judith A.²  Ewen, Stanley W.B.²  Marcus, Craig B.¹  Ah-See, A.K.⁵ 

[1] Department of Pharmacology and Toxicology, Purdue University, West Lafayette, IN 47907-1334, USA;Department of Pathology, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Molecular and Cell Biology, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Biomedical Sciences, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Surgery, University of Aberdeen, Aberdeen AB9 2ZD, UK

关键词: Breast;    Cancer;    Cytochrome P450;    Neoplasm;    P450;    cytochrome P450;    RT-PCR;    reverse transcriptasepolymerase chain reaction;   

DOI  :  10.1016/0014-5793(95)01126-Y

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.

【 授权许可】

Unknown