期刊论文详细信息
FEBS Letters
Expression of cytochrome P450 CYP1B1 in breast cancer
Melvin, William T.3  Burke, M.Danny4  Greenlee, William F.1  Murray, Graeme I.2  McKay, Judith A.2  Ewen, Stanley W.B.2  Marcus, Craig B.1  Ah-See, A.K.5 
[1] Department of Pharmacology and Toxicology, Purdue University, West Lafayette, IN 47907-1334, USA;Department of Pathology, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Molecular and Cell Biology, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Biomedical Sciences, University of Aberdeen, Aberdeen AB9 2ZD, UK;Department of Surgery, University of Aberdeen, Aberdeen AB9 2ZD, UK
关键词: Breast;    Cancer;    Cytochrome P450;    Neoplasm;    P450;    cytochrome P450;    RT-PCR;    reverse transcriptasepolymerase chain reaction;   
DOI  :  10.1016/0014-5793(95)01126-Y
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

The expression of CYP1B1 has been identified in breast cancer using the reverse transcriptase-polymerase chain reaction and immunoblotting. CYP1B1 mRNA was expressed in the majority of breast tumours and immunoblotting of breast tumours identified a single protein band of molecular weight 60 kDa corresponding to the predicted molecular weight of human CYP1B1. This is the first study to identify CYP1B1 expression in a tumour where it may represent a previously unknown pathway for the metabolism of oestradiol and chemotherapeutic drugs.

【 授权许可】

Unknown   

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