An immunodominant antigen of Brugia malayi is an asparaginyl‐tRNA synthetase

FEBS Letters

Kron, Michael²  Härtlein, Michael¹  Marquard, Kristine²  Price, Steven¹  Leberman, Reuben¹ 

[1] European Molecular Biology Laboratory, Grenoble Outstation, B.P. 156, 38042 Grenoble Cedex, France;Department of Medicine, Michigan State University, East Lansing, MI 48824, USA

关键词: Antigen;    Asparagine;    Aminoacyl-tRNA synthetase;    Filariasis;    Brugia malayi;   

DOI  :  10.1016/0014-5793(95)01092-S

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Lymphatic filariasis is caused by infection with the filarial nematodes Brugia malayi, Brugia timori, Wuchereria bancrofti and Onchocerca volvulus which collectively infect about 200 million persons throughout the world. Protein sequence homology analysis of a major nematode antigen suggested that it was a class II aminoacyl-tRNA synthetase. The overproduction, purification and verification that the major B. malayi antigen is an asparaginyl-tRNA synthetase is described.

【 授权许可】

Unknown