Molecular cloning of a widely expressed human homologue for the Drosophila trp gene

FEBS Letters

Chu, Phillip B.¹  Zhu, Xi¹  Peyton, Michael¹  Birnbaumer, Lutz¹ 

[1] Department of Anesthesiology and Biological Chemistry, UCLA School of Medicine, Box 951778, BH612, CHS, Los Angeles, CA 90095-1778, USA

关键词: Transient receptor potential;    Calcium influx channel;    Ca2+ signaling;    EST;    expressed sequence tag;    IP3;    inositol 1;    4;    5-trisphosphate;    PLC;    phosphoinositide-specific phospholipase C;    trp;    transient receptor potential;    trpl;    trp-like;    Htrp-1;    human trp-1;   

DOI  :  10.1016/0014-5793(95)01038-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The Drosophila transient receptor potential (trp) gene and its homologue, trpl, have been suggested to mediate calcium entry during the insect's phototransduction process. We isolated a human cDNA, human trp-1 (Htrp-1), encoding a polypeptide of 793 amino acids that is 37% identical (62% similar) to Drosophila trp and trpl. Northern analysis showed that the Htrp-1 transcript is approximately 5.5 kb and expressed in most human tissues, with higher amounts in ovary, testis, heart, and brain. Isolation of Htrp-1 suggests that a trp-type protein is present in mammals and should provide a useful tool in studying calcium-depletion induced calcium influx processes.

【 授权许可】

Unknown