Nitric oxide and oxygen radicals: a question of balance

FEBS Letters

Darley-Usmar, Victor³  Wiseman, Helen²  Halliwell, Barry¹ 

[1] Neurodegenerative Disease Research Centre, King's College London, Manresa Road, London SW3 6LX, UK;Department of Nutrition and Dietetics, King's College London, Campden Hill Road, London W8 7AH, UK;Biology Division, Wellcome Research Laboratories, Langley Court Beckenham, Kent, BR3 3BS, UK

关键词: Nitric oxide;    Superoxide;    Reactive nitrogen species;    Peroxynitrite;    Oxygen radicals;   

DOI  :  10.1016/0014-5793(95)00764-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The production of superoxide and nitric oxide individually has been associated with the development of several diseases but only recently has it been realised that interactions between them may also be important in disease pathology. The central hypothesis which is emerging is that the balance between nitric oxide and superoxide generation is a critical determinant in the aetiology of many human diseases including atherosclerosis, neurodegenerative disease, ischaemia-reperfusion and cancer. These ideas are discussed in this short overview and placed in the context of the current and future status of therapies which could modulate the balance between nitric oxide and superoxide.

【 授权许可】

Unknown