The Grb2 adaptor

FEBS Letters

Cussac, Didier¹  Maignan, Sébastien²  Chardin, Pierre¹  Ducruix, Arnaud² 

[1] Institut de Pharmacologie Moléculaire et Cellulaire du CNRS 660, route des Lucioles, 06560 Valbonne, France;Laboratoire de Biologie Structurale, CNRS, 91198 Gif sur Yvette, France

关键词: Grb2;    Ras;    Sh2 domain;    SH3 domain;    Sos;    Tyrosine kinase;   

DOI  :  10.1016/0014-5793(95)00578-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Grb2 is an ‘adaptor’ protein made of one SH2 and two SH3 domains. The SH3 domains bind to prolinerich motifs in the C-terminal part of the ras exchange factor Sos. Binding of the Grb2 SH2 domain to phosphotyrosine motifs on receptors, or other adaptor proteins such as Shc, recruits this Grb2/Sos complex at the plasma membrane where Sos stimulates nucleotide exchange on ras, then ras activates raf and leads to MAP kinase activation. The structure of Grb2, the precise motifs recognised by its SH2 and SH3 domains, the way Grb2 performs its function, a possible regulation of its association with Sos, and its ability to complex with other proteins in vivo, are discussed.

【 授权许可】

Unknown