Genetic disorders of the red cell membranes

FEBS Letters

Delaunay, Jean¹ 

[1] Laboratoire de Génétique Moléculaire Humaine (CNRS URA 1171), Institut Pasteur de Lyon, 69365 Lyon Cedex 07, France

关键词: Red cell;    Membrane;    Protein;    Hereditary hemolytic anemia;    Genomic mutation;   

DOI  :  10.1016/0014-5793(95)00460-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The red cell membrane is comprised of a lipid bilayer studded with transmembrane proteins, and laminated by a protein network, the membrane skeleton, at the surface of the inner monolayer. The erythrocyte owes its mechanical properties to the membrane skeleton. Hereditary spherocytosis, hereditary elliptocytosis or poikilocytosis, Southeast Asian ovalocytosis are hereditary hemolytic anemias, due to mutations in the genes encoding ankyrin, the anion exchanger, spectrin, protein 4.1 or protein 4.2, which are main proteins of the membrane. Recent advances in the field have led to fundamental questions.

【 授权许可】

Unknown