From entangled membranes to eclectic morphologies: cubic membranes as subcellular space organizers

FEBS Letters

Landh, Tomas¹ 

[1] Department of Biophysical Sciences and Biomaterials, State University of New York at Buffalo, Buffalo, NY 14214, USA

关键词: Transmission electron microscopy;    Image analysis;    Cell space organization;    Cell membrane;    Cubic membrane;    2D;    two-dimensional;    3D;    three-dimensional;    DTC;    direct template correlation;    D;    double diamond;    G;    gyroid;    PCS;    periodic cubic structures;    P;    primitive;    SER;    smooth endoplasmic reticulum;    TEM;    transmission electron miscroscopy;   

DOI  :  10.1016/0014-5793(95)00660-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The identification of evolutionary conserved membrane morphologies whose architecture is governed by cubic symmetry — cubic membranes — adds a new dimension to cell membrane functions and, perspicuously, to their role in subcellular space organization. Through analysis of electron micrographs, three families of cubic membranes have been unequivocally identified in which one or more (parallel) membranes, described by periodic cubic surfaces, partition space into two or more independent, albeit convoluted, subspaces of membrane potential determined dimensions. The choice of a particular cubic symmetry is suggested to be due to its activity. Here the architecture and function of multiple (≥ 3) subspace organization in classical membrane bound organelles is addressed. As it can be precisely determined with cubic membranes suggests that they can be employed as a reference morphology.

【 授权许可】

Unknown