Antioxidant potential of intermediates in phenylpropanoid metabolism in higher plants

FEBS Letters

Rice-Evans, Catherine¹  Paul Bolwell, G.²  Melikian, Narbeh¹  Castelluccio, Cinzia¹  Sampson, Julia¹  Paganga, George¹  Pridham, John² 

[1] Free Radical Research Group, Division of Biochemistry and Molecular Biology, UMDS- Guy's Hospital, St. Thomas's Street, London SE1 9RT, UK;Department of Biochemistry, Royal Holloway - University of London, Egham, Surrey TW20 0EK, UK

关键词: Antioxidant activity;    Hydroxycinnamic acid;    Phenylpropanoid metabolism;    Higher plants;   

DOI  :  10.1016/0014-5793(95)00639-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In this study the antioxidant activities of the hydroxycinnamic acids, chlorogenic, caffeic, ferulic and p-coumaric have been investigated in peroxidising lipid systems mediated by metmyoglobin. The results show that the order of effectiveness in increasing the resistance of LDL to peroxidation, in protecting LDL cholesterol from oxidation and preventing the oxidative modification of the LDL apoprotein B₁₀₀ is caffeic = chlorogenic > ferulic > p-coumaric acid. Assessment of the rates of reaction of the hydroxycinnamates with ferrylmyoglobin, a product of the reductive decomposition of lipid hydroperoxides, reveals that the compounds are more effective as peroxyl radical scavengers than reductants of ferryl myoglobin in peroxidising LDL systems mediated by haem proteins.

【 授权许可】

Unknown