The third nucleotide of the Gly coding triplet remembers the periodicity of the collagen chain

FEBS Letters

Tumanyan, V.G.¹  Makeev, V.Ju.¹  Esipova, N.G.¹ 

[1] V.A. Engelgardt Molecular Biology Institute RAS, Moscow, Russian Federation

关键词: Collagen;    Gene duplication;    Sequence analysis;    Sequence Fourier transform;   

DOI  :  10.1016/0014-5793(95)00490-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Collagen is a fibrous protein with a primary structure with complex periodical features. We show using symbolic Fourier transform of the collagen cDNA sequence that basic periodical patterns appear there also. Strikingly they are present in the third position of triplets encoding Gly, which occupies each third position in the sequence of the protein, and to which selection on the protein level does not applied. Thus, the gene of collagen seems to appear due to pra-gene multiplication.

【 授权许可】

Unknown