Cadherin‐dependent cell aggregation is affected by decapeptide derived from rat extracellular super‐oxide dismutase

FEBS Letters

Mège, René-Marc¹  Willems, Jean⁴  Mareel, Marc³  Bruyneel, Erik³  Slegers, Herman²  Noë, Veerle³  Zwijsen, An² 

[1] INSERM U153, Rue du Fer-à-Moulin, F 75005 Paris, France;Department of Biochemistry, University of Antwerp, B 2610 Wilrijk, Antwerpen, Belgium;Department of Radiotherapy, Nuclear Medicine and Experimental Cancerology, University Hospital, B 9000 Gent, Belgium;Interdisciplinary Research Center, KULAK, B 8500 Kortrijk, Belgium

关键词: Superoxide dismutase;    Cadherin;    Cell aggregation;    EC-SOD;    extracellular superoxide dismutase;    HAV;    hisala-val;    all peptides are described in the one-letter code;   

DOI  :  10.1016/0014-5793(95)00334-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A synthetic HAV-containing decapeptide homologous to the amino acid sequence ⁴⁴R-Q⁵³ in rat extracellular superoxide dismutase B affects cadherin-dependent cell aggregation. Cell lines, some of them transfected, expressing different types of cadherins were tested using in vitro cell aggregation and cell dissociation assays. A concentration-dependent inhibition of aggregation by the EC-SOD-derived HAV-containing peptide was detected only in N-cadherin expressing cells. These results suggest the localisation and possible protective role of EC-SOD B for cells expressing N-cadherin.

【 授权许可】

Unknown