Retardation by the soybean Bowman‐Birk inhibitor of elastin hydrolysis catalyzed by leukocyte proteinases

FEBS Letters

Gladysheva, Inna P.¹  Tikhonova, Tamara V.¹  Larionova, Natalia I.¹ 

[1] Department of Chemistry, M.V. Lomonosov Moscow State University, Moscow 000958, Russian Federation

关键词: Bowman-Birk soybean inhibitor;    Human leukocyte elastase;    Human leukocyte cathepsin G;    Elastin;    BBI;    classical soybean Bowman-Birk protease inhibitor;    BPTI;    basic pancreatic trypsin inhibitor;    DMSO;    dimethyl sulfoxide;    HLE;    human leukocyte elastase;    HLCG;    human leukocyte cathepsin G;    MeOSuc-Ala-Ala-Pro-Val-pNA;    methoxysuccinyl-Ala-Ala-Pro-Val-p-nitroanilide;    α 1-PI;    α 1-proteinase inhibitor;    Suc-Ala-Ala-Pro-Phe-pNA;    succinyl-Ala-Ala-Pro-Phe-p-nitroanilide;    F st;    stimulation factor;   

DOI  :  10.1016/0014-5793(95)00202-K

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The classical Bowman-Birk inhibitor from soya retards strongly the hydrolysis of elastin catalyzed by leukocyte elastase, cathepsin G and a mixture of both. The inhibitory effect is practically unaffected by both the adsorption of the enzymes on elastin and prolongation of the enzymatic reaction.

【 授权许可】

Unknown