Phase separation in cytoplasm, due to macromolecular crowding, is the basis for microcompartmentation

FEBS Letters

Brooks, Donald E.¹  Walter, Harry² 

[1] Departments of Pathology and Chemistry, University of British Columbia, Vancouver, BC, V6T 1W5, Canada;Laboratory of Chemical Biology 151, Veterans Affairs Medical Center, Long Beach, CA 90822-5201, USA

关键词: Aqueous phase system;    Cytoplasm;    Macromolecular crowding;    Microcompartmentation;    Phase separation;   

DOI  :  10.1016/0014-5793(95)00159-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The macromolecular diversity and concentrations in the fluid phase of cytoplasm constitute conditions necessary and sufficient for aqueous phase separation. Consequences of phase separation in cytoplasm, including its ‘compartmentation’, are inferred from analogies with the physicochemical properties of aqueous two-phase systems and with the partitioning behavior of biomaterials in them.

【 授权许可】

Unknown