Regulation of cytochrome c expression in the aerobic respiratory yeast Kluyveromyces lactis

FEBS Letters

Freire-Picos, M.Angeles¹  Cerdan, M.Esperanza¹  Hollenberg, Cornelis P.²  Breunig, Karin D.² 

[1] Departamento de Biologia Celular y Molecular, Universidad de La Coruña, Campus de La Zapateira sln, 15071-La Coruña, Spain;Institut für Mikrobiologie, Heinrich-Heine-Universität Düsseldorf, Universitätsstrasse 1, D-40225 Düsseldorf 1, Germany

关键词: Cytochrome c gene;    Kluyveromyces lactis;    Transcriptional regulation;   

DOI  :  10.1016/0014-5793(95)00016-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transcriptional regulation of the KlCYC1 gene from the aerobic respiratory yeast Kluyveromyces lactis has been studied. The KlCYC1 gene produces two transcripts of different sizes, in contrast with the single transcripts found for CYC1 and CYC7 from Saccharomyces cerevisiae, and for the CYC gene from Schwanniomyces occidentali. Both KlCYC1 transcripts respond in the same way to the regulatory signals studied here. The transcription of KlCYC1 is regulated by oxygen and this control is mediated by heme. The KlCYC1 gene is also subject to catabolite repression. Heterologous expression in S. cerevisiae mutants reveals that the factors HAP1 and HAP2 take part in the regulatory mechanism.

【 授权许可】

Unknown