A critical mutation in both WT1 alleles is not sufficient to cause Wilms' tumor

FEBS Letters

Yoneyama, Hiroshi²  Hata, Jun-ichi¹  Akasaka, Yoshikiyo³  Kato, Shingo⁴  Kurosawa, Yoshihiro²  Kikuchi, Haruhito¹ 

[1] Department of Pathology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 130, Japan;Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 130, Japan;2nd Department of Pathology, Toho University School of Medicine, 5-21-16 Ohmorinishi, Ohta-ku 143, Tokyo, Japan;Department of Microbiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 130, Japan

关键词: Wilms' tumor;    WT1 gene;   

DOI  :  10.1016/0014-5793(95)00071-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The WT1 gene is a tumor suppresser gene for Wilms' tumor (WT). Inactivation of both alleles has been proposed as the cause of WT. We encountered a patient with Denys-Drash syndrome associated with WT whose WT1 gene had a homozygous point mutation not only in WT but also in renal tissue adjacent to the WT and in the germline. These findings indicate that factor(s) other than the loss of WT1 are required for WT to develop.

【 授权许可】

Unknown