A ciliary K+ conductance sensitive to charibdotoxin underlies inhibitory responses in toad olfactory receptor neurons

FEBS Letters

Bacigalupo, Juan¹  Labarca, Pedro¹  Morales, Bernardo¹ 

[1] Departamento de Biologia, Facultad de Ciencias, Universidad de Chile, Casilla 653, Santiago, Chile

关键词: Inhibitory response;    Ca2+-activated K+ channel;    Charibdotoxin;    Odorant;    Olfactory neuron;   

DOI  :  10.1016/0014-5793(95)00008-W

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In olfactory neurons from Caudiverbera caudiverbera, a mixture of putrid odorants trigger an inhibitory, K⁺-selective current and a hyperpolarizing receptor potential. The current-voltage relation resembles that of a Ca²⁺-activated K⁺ conductance; their amplitude depends on extracellular Ca²⁺. 10 nM charibdotoxin, a blocker of K⁺-selective channels, including Ca²⁺-activated ones, reversibly abolished inhibitory currents and receptor potentials. Focal stimulation demonstrates that the underlying transduction mechanism is confined to the cilia. This represents the first evidence for inhibitory responses in vertebrate olfactory cells mediated by a ciliary CTX-sensitive K⁺ conductance, most likely a Ca²⁺-activated one.

【 授权许可】

Unknown