Pro‐oxidant effects of 7‐hydroperoxycholest‐5‐en‐3β‐ol on the copper‐initiated oxidation of low density lipoprotein

FEBS Letters

Rodriguez, C.¹  Blache, D.²  Davignon, J.¹ 

[1] Département de Recherches sur les Lipides et l'Athérosclérose, Institut de Recherches Cliniques de Montreal, Montreal, Qué., Canada;INSERM CJF 93-10, Laboratoire de Biochimie des Lipoprotéines, Université de Bourgogne, 7 bd Jeanne d'Arc 21033, Dijon, France

关键词: Cholesterol hydroperoxide;    Aged cholesterol;    Oxysterol;    Oxidized LDL;    Oxidation;    Copper;   

DOI  :  10.1016/0014-5793(94)01348-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In low density lipoproteins (LDL) supplemented with aged cholesterol and oxidized in the presence of Cu²⁺, an increase of the lipid oxidation parameters was observed compared with pure cholesterol-enriched LDL. A compound, identified as 7-hydroperoxycholesterol (7HPC), isolated from aged cholesterol and added to LDL, reproduced the above effects. The results indicate that the pro-oxidant effect of 7HPC is dependent on the hydroperoxy group since the corresponding alcohol derivative, 7α-hydroxycholesterol, had no such effect. These data suggest that among the LDL-associated lipid peroxides, cholesterol peroxides may have important implications in the susceptibility of this lipoprotein to oxidation.

【 授权许可】

Unknown