Transcriptional repression mediated by the serum response factor

FEBS Letters

Ernst, Wolfram H.¹  Janknecht, Ralf¹  Cahill, Michael A.¹  Nordheim, Alfred¹ 

[1] Institut für Molekularbiologie, Medizinische Hochschule Hannover, D-30623 Hannover, Germany

关键词: c-fos;    Serum response factor;    Squelching;    TATA-box binding protein;    Transcription regulation;   

DOI  :  10.1016/0014-5793(94)01321-Q

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The serum response element (SRE) contributes to transcriptional repression of the c-fos proto-oncogene. We show that the transcription factor SRF is able to repress SRE-dependent transcription, apparently by sequestering a co-activator. Only the DNA-binding core region is required for this SRE-dependent repression. Furthermore the phosphorylation status at potential casein kinase II sites within an N-terminal repression domain affects SRE-independent transcription. SRF may thus pleiotropically influence cellular transcription, representing a novel aspect of SRF function.

【 授权许可】

Unknown