The role of water in the mechanism of muscular contraction

FEBS Letters

Oplatka, Avraham¹ 

[1] Department of Structural Biology, Weizmann Institute of Science, Rehovot 76100, Israel

关键词: Actin;    Hydration forces;    Muscle contraction;    Myosin;    Swinging Crossbridge theory;    Water;   

DOI  :  10.1016/0014-5793(94)01158-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Twenty-five years after its proposal, the swinging theory of muscular contraction, in which the majority of scientists in the field have blindly believed, has not yet been verified. Rapidly growing experimental evidence indicates that the myosin heads do not swing. It is time to look for an alternative mechanism. Data is presented indicating that water is liberated during tension development and the extent to which it is released appears to affect the degree of tension. Since water can move (because of acquired extra energy, involvement in hydration forces etc.), it might cause protein movement.

【 授权许可】

Unknown