A proposed structure for ‘Family 18’ chitinases a possible function for narbonin

FEBS Letters

Coulson, Andrew F.W.¹ 

[1] Biocomputing Research Unit, Institute for Cell and Molecular Biology, University of Edinburgh King's Buildings, Mayfield Road, Edinburgh EH9 3JR, UK

关键词: Narbonin;    Chitinase;    Glycosyl hydrolase;    TIM barrel;   

DOI  :  10.1016/0014-5793(94)01084-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The sequence of narbonin, a leguminous seed protein with the TIM barrel structure but of unknown function, is significantly similar to endo-β-N-acetylglucosaminidase H from Streptomyces plicatus. This protein is a member of a family of chitinases, ‘Family 18’ of the glycosyl hydrolases. It is proposed that the catalytic domain of this family has the TIM barrel structure. It is proposed that narbonin has chitinase activity, or has been derived from a chitinase by loss of function.

【 授权许可】

Unknown