Influence of the conformation of a macromolecule on the generation of T‐cell proliferative response A study with model polypeptides

FEBS Letters

Delmas, A.¹  Lacassie, E.¹  Trudelle, Y.¹ 

[1]Centre de Biophysique Moléculaire, CNRS, 1A avenue de la Recherche Scientifique, 45071 Orléans cédex 2, France

关键词: T-cell epitope;    Polypeptide;    Conformation;    α-Helix;    Aggregation;   

DOI  :  10.1016/0014-5793(94)00708-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To study the influence of the conformation of polypeptidic macromolecules on the generation of T-cell epitopes, sequential polypeptides with an octamer repeat unit were designed and synthesized. They adopt mainly unordered and α-helical conformations. Among these polypeptides, those containing proline are fully or partly unordered, and are more effective at inducing T-cell proliferation than a proline-free very stable α-helical polypeptide. This extremely stable α-helical conformation, probably stabilized by aggregation, would enhance its stability against proteolytic processing.

【 授权许可】

Unknown