Binding of retinoids to uteroglobin

FEBS Letters

Martinez, M.Pérez¹  Nieto, A.¹  de Haro, M.S.López¹  García, C.¹ 

[1] Centro de Biologia Molecular ‘Severo Ochoa’, Universidad Autónoma de Madrid, 28049-Cantoblanco, Madrid, Spain

关键词: Retinoid;    Progesterone;    Steroid-binding protein;    Reproductive tract;   

DOI  :  10.1016/0014-5793(94)00678-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Uteroglobin, a progesterone-binding secretory protein, was shown to bind retinoic acid and retinol in a non-saturable manner, at least up to concentrations of retinoids of 20 μM. Binding is increased about 10-fold by previous reduction of uteroglobin with 10 mM dithothreitol and it is not affected by previous saturation of the progesterone binding site, suggesting different binding sites for the steroid and the retinoids. The results are discussed in relation to a possible physiological role for this protein.

【 授权许可】

Unknown