Autoregulation of the human WT1 gene promoter

FEBS Letters

Poirier, Veronique¹  Brown, Keith W.¹  Malik, Karim T.A.¹  Ivins, Sarah M.¹ 

[1] CLIC Research Unit, Department of Pathology & Microbiology, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, UK

关键词: Wilms tumour gene;    Promoter regulation;    IGFII;    insulin-like growth factor II;    PDGF-A;    platelet-derived growth factor A;    SSC;    standard saline citrate;    DMEM;    Dulbeeco's modification of Eagle's medium;    bp;    base-pairs;    kb;    kilobases;   

DOI  :  10.1016/0014-5793(94)00642-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The human Wilms tumour suppressor gene, WT1, encodes a zinc-finger protein which can function as a transcriptional activator or suppressor. This study reports the analysis of the human WT1 gene promoter, and demonstrates that high levels of WT1 expression lead to autosuppression of the WT1 promoter. Deletion analyses of the promoter region implicate sequences 5′ and 3′ of the transcriptional start site as being crucial in WT1 autosuppression. Loss or alteration of this function of WT1 may be important in tumourigenesis.

【 授权许可】

Unknown