One of the retinoic acid‐inducible cDNA clones in mouse embryonal carcinoma F9 cells encodes a novel isoenzyme of fructose 1,6‐bisphosphatase

FEBS Letters

Shimada, Kazunori¹  Takihara, Yoshihiro¹  Yasunaga, Teruo²  Nomura, Midori¹ 

[1] Department of Medical Genetics, Division of Molecular Biomedicine, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565, Japan;Genome Information Research Center, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565, Japan

关键词: Differentiation;    Gluconeogenesis;    Intestine;    Evolution;   

DOI  :  10.1016/0014-5793(94)00608-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Rae-30, one of the retinoic acid (RA)-inducible cDNA clones in mouse embryonal carcinoma F9 cells, was sequenced and the deduced RAE-30 protein showed about a 70% homology to mammalian fructose 1,6-bisphosphatase (EC 3.1.3.11) (FBPase), in comparison to over 85% homology observed among the previously documented rat liver, pig kidney and human leukemic HL-60 cell FBPases. The Rae-30 mRNAs were not detected in various tissues of adult mice, including the liver and kidney, but were detected in a placenta and predominantly in the intestine of adult mice. These findings indicate that the Rae-30 cDNA encodes a novel isoenzyme of FBPase, which is likely to be involved in early differentiation in mammalian cells.

【 授权许可】

Unknown