A new UV‐filter compound in human lenses

FEBS Letters

Carver, John A.¹  Zhu, Jiulin¹  Kilby, Greg W.¹  Wood, Andrew M.¹  Truscott, Roger J.W.¹  Stutchbury, Glen M.¹  Sheil, Margaret M.¹ 

[1]Australian Cataract Research Foundation, University of Wollongong, Northfields Avenue, Wollongong, N.S.W. 2522, Australia

关键词: Ultraviolet light;    Photooxidation;    Cataract;    Lens;    Tryptophan;    Filter;   

DOI  :  10.1016/0014-5793(94)00601-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A new UV-filter compound, 4-(2-amino-3-hydroxyphenyl)-4-oxobutanoic acid O-glucoside, has been identified in human lenses. The structure suggests that it is derived biosynthetically from tryptophan. Quantification studies on the new compound show that it is the second-most abundant UV-filter compound in the lens with an absorption and fluorescence spectrum similar to that of 3-hydroxykynurenine glucoside.

【 授权许可】

Unknown