期刊论文详细信息
FEBS Letters | |
KEKE motifs | |
Rogers, Scott W.2  Rechsteiner, Martin1  Realini, Claudio1  | |
[1] Departments of Biochemistry, Anatomy/VA-GRECC, University of Utah, Salt Lake City, UT 84132, USA;Department of Neurobiology and Anatomy/VA-GRECC, University of Utah, Salt Lake City, UT 84132, USA | |
关键词: Irradiation; Thymocyte apoptosis; Protein kinase C; Phospholipase A2; A23187; calcium ionophore; BPB; 4-bromophenacylbromide; [Ca2+]i; cytosolic concentration of Ca2+; GAP; GTPase activating protein; H7; 1-(5-isoquinolinylsulfonyl)-2-methylpiperasine dihydrochloride; HEPES; 4-(2-hydroxyethyl)-1-piperasineethane-sulfonic acid; IP3; inositol triphosphate; PIP2; phosphoinositol 4; 5-biphosphate; PLC; phospholipase C; PMA; phorbol 12-myristate 13-acetate; PTK; protein-tyrosine kinase; PKC; protein kinase C; PLA2; phospholipase A2; | |
DOI : 10.1016/0014-5793(94)00569-9 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A stretch of 28 ‘alternating’ lysine (K) and glutamate (E) residues is found in an activator of the multicatalytic protease. Such ‘KEKE sequences’ are also present in subunits of the multicatalytic protease, in subunits of the 26S protease and in a variety of chaperonins. We propose that KEKE regions promote association between protein complexes. Furthermore, they may contribute to the selection of peptides presented on MHC Class I receptors.
【 授权许可】
Unknown
【 预 览 】
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RO201912020299734ZK.pdf | 549KB | download |