Activation of human peripheral monocytes by angiotensin II

FEBS Letters

Jonas, Uwe¹  Hahn, Alfred W.A.¹  Bühler, Fritz R.¹  Resink, Thérèse J.¹ 

[1] Department of Research, Laboratory for Vascular Biology, University Clinics Basel, Hebelstrasse 20, CH 4031 Basel Switzerland

关键词: Monocyte;    Angiotensin II;    AT1 receptor;    Activation;    Adhesion;    Tumor necrosis factor α;   

DOI  :  10.1016/0014-5793(94)00531-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

This study has investigated the ability of the vasoconstrictor peptide angiotensin II to activate human peripheral blood monocytes. Activation was monitored by measuring both the release of tumor necrosis factor α from monocytes and their adhesion to monolayers of human endothelial cells. Angiotensin II-elicited activation of monocytes was dose-dependent (half-maxiinally effective concentration ≈ 0.2 nM), saturable (maximally effective concentration ≈ 5 nM), and sensitive to inhibition by the angiotensin type 1 receptor antagonist ZD 7155. Such direct actions imply that angiotensin II is an important candidate stimulus for the subendothelial infiltration of monocytes observed in atherogenesis and hypertension.

【 授权许可】

Unknown