Functional role of a consensus peptide which is common to α‐, β‐, and γ‐tubulin, to actin and centractin, to phytochrome A, and to the TCP1α chaperonin protein

FEBS Letters

Surridge, Christopher D.¹  Burns, Roy G.¹ 

[1] Biophysics Section, Blackett Laboratory, Imperial College of Science, Technology and Medicine, Prince Consort Road, London SW7 2BZ, UK

关键词: α-Tubulin;    β-Tubulin;    γ-Tubulin;    Actin;    Centractin;    Phytochrome A;    TCP1α;    Consensus peptide;    Protein folding;   

DOI  :  10.1016/0014-5793(94)00522-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The TRiC (TCP1 Ring Complex) chaperonin complex participates in the functional folding of actin, centractin, α-,β-,γ-tubulin, and phytochrome. Each of the cytoskeletal proteins contain a peptide, RK(A,C,T)F/KRAF, located towards the C-terminus, which is homologous to a TCP1α peptide, while the equivalent phytochrome peptide (RLKAF in certain isoforms) is very similar to the KLRAF peptide of TCP1α. We propose that this TCP1α peptide binds to the nascent polypeptides as they emerge from the ribosome, that this binding restricts the folding pathway, and that the TCP1α peptide is subsequently displaced by the synthesis of the consensus peptide. This hypothesis is strongly supported by the crystallographic structure of actin.

【 授权许可】

Unknown