Human interleukin‐13 activates the interleukin‐4‐dependent transcription factor NF‐IL4 sharing a DNA binding motif with an interferon‐γ‐induced nuclear binding factor

FEBS Letters

Alliger, Peter²  Köhler, Ingrid²  Höll-Neugebauer, Bärbel²  Minty, Adrian¹  Rank, Gerti²  Rieber, Ernst Peter²  Ferrara, Pascual¹  Caput, Daniel¹ 

[1]Sanofi Elf Bio Recherches, 31676 Labège, France

[2]Institute for Immunology, University of Munich, Goethestr. 31, D-80336 Munich, Germany

关键词: Interleukin-4;    Interleukin-13;    Interferon-γ;    Signal transduction;    Nuclear binding factor;    Responsive element;   

DOI  :  10.1016/0014-5793(94)00438-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effects of interleukin-13 (IL-13) and interleukin-4 (IL-4) on cellular functions were shown to be quite similar. We provide evidence that in monocytes as well as in T lymphocytes both IL-4 and IL- 13 activate the same recently identified transcription factor NF-IL4 which binds to the specific responsive element IL-4RE. In addition, we show that a nuclear factor activated by interferon-γ also interacts with the IL-4RE. It differs from NF-IL4 in the electrophoretic mobility of the complex with DNA, in its DNA-binding specificity and in the proteins interacting with the DNA sequence. Sensitivity against various enzyme inhibitors suggests that components of the signal transduction pathway are shared by all three cytokines.

【 授权许可】

Unknown