β‐Cyclodextrin interacts with the Alzheimer amyloid β‐A4 peptide

FEBS Letters

Hewlett, David R.²  Haskins, Neville J.¹  Camilleri, Patrick¹ 

[1] Departments of Analytical Science, SmithKline Beecham Pharmaceuticals, The Frythe, Welwyn, Herts. A5L6 9AR, UK;Molecular Neuropathology, SmithKline Beecham Pharmaceuticals, Coldharbour Road, Harlow, Essex, CM19 5AD, UK

关键词: Amyloid;    A4 peptide;    Alzheimer's disease;    β-Cyclodextrin;    Electrospray ionisation mass spectrometry;    Fibrillisation;   

DOI  :  10.1016/0014-5793(94)80467-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Electrospray ionisation mass spectrometry has been used to show that the synthetic 40 amino acid β-amyloid peptide (β1-40) interacts with the cyclic oligosaccharide β-cyclodextrin. This interaction, presumably with the hydrophobic aromatic moieties on the peptide, has been shown to diminish substantially the neurotoxic effects of β1-40 in a cell line.

【 授权许可】

Unknown