Receptor‐mediated endocytosis of plasminogen activators and activator/inhibitor complexes

FEBS Letters

Andreasen, Peter A.¹  Moestrup, Søren K.²  Nykjær, Anders²  Sottrup-Jensen, Lars¹  Gliemann, Jørgen²  Petersen, Claus Munch²  Kjøller, Lars¹ 

[1] Department of Molecular Biology, University of Aarhus, 130 C.F. Møller's Allé, 8000 Aarhus C, Denmark;Department of Medical Biochemistry, University of Aarhus, 8000 Aarhus C, Denmark

关键词: α2-Macroglobulin;    Glycosyl phosphatidyl inositol;    Plasminogen activator;    Proteolysis;    Receptor;    Serine proteinase;    Serpin;    α2M;    α2-macroglobulin;    α2MR;    α2-macroglobulin receptor/low density lipoprotein receptor related protein;    RAP;    α2-macroglobulin receptor-associated protein;    EGF;    epidermal growth factor;    gp330;    epithelial glycoprotein 330;    GPI;    glycosyl phosphatidyl inositol;    PAI-1;    type-1 plasminogen activator inhibitor;    PAI-2;    type-2 plasminogen activator inhibitor;    t-PA;    tissue-type plasminogen activator;    u-PA;    urokinase-type plasminogen activator;    u-PAR;    urokinase receptor;   

DOI  :  10.1016/0014-5793(94)80276-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent findings have elucidated the mechanism for clearance from the extracellular space of the two types of plasminogen activators, urokinase-type plasminogen activator (u-PA) and tissue-type plasminogen activator (t-PA), and their type-1 inhibitor (PAI-1). Activator/PAI-1 complexes and uncomplexed t-PA bind to the multiligand receptors α₂ macroglubulin receptor/low density lipoprotein receptor-related protein (α₂MR) and epithelial glycoprotein 330 (gp330). These receptors mediate endocytosis and degradation of u-PA/PAI-1 complex bound to the glycosyl phosphatidyl inositol-anchored urokinase receptor (u-PAR) on cell surfaces, and participate, in cooperation with other receptors, in hepatic clearance of activator/PAI-1 complexes and uncomplexed t-PA from blood plasma. The α₂MR- and gp330-mediated endocytosis of a ligand (u-PA/PAI-1 complex) initially bound to another receptor (u-PAR) is a novel kind of interaction between membrane receptors. Binding to α₂MR and gp330 is a novel kind of molecular recognition of serine proteinases and serpins.

【 授权许可】

Unknown