Changes in α1‐adrenoceptor coupling to Ca2+ channels during development in rat heart

FEBS Letters

Pang, Peter K.T.¹  Liu, Qin-Yue¹  Karpinski, Edward¹ 

[1] Department of Physiology, University of Alberta, Edmonton, Alberta, T6G 2H7, Canada

关键词: α1-adrenoceptor;    Ca2+ channel current;    Neonatal rat ventricular cell;    Young rat ventricular cell;   

DOI  :  10.1016/0014-5793(94)80371-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has been reported in the literature that α₁,-adrenoceptor activation in adult rat heart does not cause an increase in Ca²⁺ current but involves a decrease in I _t. This may explain in part the positive inotropic effect of α₁-adrenoceptor activation. In this study, the effect of phenylephrine, an α-adrenergic agonist, on L-type Ca²⁺ channel current was compared in young and neonatal rat myocytes. In the presence of propranolol, phenylephrine increased the Ca⁺ current (reversed by prazosin) in neonatal but not in young rat myocytes suggesting that the coupling of the α₁-adrenoceptor to Ca²⁺ channels may switch during development.

【 授权许可】

Unknown