Anaesthetic phencyclidine, blocker of the ATP‐sensitive potassium channels

FEBS Letters

Alekseev, Alexey E.¹  Povzun, Alexander A.¹  Peres-Saad, Hector¹  Korystova, Antonina F.¹  Kokoz, Yuri M.¹ 

[1] Laboratory of Functional Biochemistry, Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142292, Russian Federation

关键词: ATP-sensitive K-channel;    Phencyclidine;    Calcium current;    Cardiomyocyte;    Patch clamp;    ATP;    adenosine-triphosphate;    MOPS;    (3-[N-morpholino]propanesulfonic) acid;    EGTA;    ethylene glycol bis(2-aminoethylether)-N;    N';    N';    N'-tetraacetic acid;    PCP;    phencyclidine;    (1-[1-phenylcyclohexyl]-piperidine);   

DOI  :  10.1016/0014-5793(94)80208-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The double sucrose gap and patch-clamp studies revealed that phencyclidine blocked the ATP-sensitive K⁺ channel in isolated cardiac cells (half-maximal inhibition at ≈20 μM; Hill coefficient ≈1). 10μM phencyclidine increased the inward Ca²⁺ current and blocked the outward K⁺ current in the frog auricle trabeculae. The phencyclidine effects on the frog auricle trabeculae and the isolated cardiac cells proved to be quite reversible.

【 授权许可】

Unknown