FEBS Letters | |
Modulation of mammalian cell proliferation by a modified tRNA base of bacterial origin | |
Reisser, Thomas1  Kersten, Helga1  Langgut, Werner1  Nishimura, Susumu2  | |
[1] Institut für Biochemie der Medizinischen Fakultät, Universität Erlangen-Nürnberg, Fahrstrasse 17, D-91054 Erlangen, Germany;Biology Division, Natlonal Cancer Center Research Insitute, Tsukiji-5-chome, chuo-ku, Tokyo, Japan | |
关键词: Queuine; Cell proliferation; Hypoxia; Oncogenic transformation; tRNA modification; Aerobic glycolysis; | |
DOI : 10.1016/0014-5793(93)81627-C | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Addition of the q-base to q-deflcient non-transformed mammalian cells stimulated their proliferation. The q-base also improved proliferation of some cancer-derived cell lines, but inhibited proliferation of others. The proliferation of HeLa-S3 carcinoma cells was stimulated by q under aerobic conditions, but was inhibited when the cells had shifted their energy metabolism towards glycolysis as the result of oxygen limitation. Q-deficient cells could not adapt their proliferation to the respective oxygen tension. The q-base stimulated the proliferation of non-transformed fibroblasts but inhibited proliferation of the same cell line, when aerobic glycolysis was increased after transformation with the ras gene. The results suggest that the q-base permits mammalian cells to adapt their proliferation to their specific metabolic state.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201912020298891ZK.pdf | 735KB | download |