Carcinogens stimulate phosphorylation of ethanolamine derived from increased hydrolysis of phosphatidylethanolamine in, C3H/101/2 fibroblasts

FEBS Letters

Anderson, Wayne H.¹  Crilly, Karan S.¹  Kiss, Zoltan¹ 

[1] The Hormel Institute, University of Minnesota, 801 16th Avenue NE, Austin, MN 55912, USA

关键词: Ethanolamine phosphate;    Phosphatidylethanolamine;    7;    12-Dimethyl-benz[a]anthracene;    Benzo[a]pyrene;    Fibroblast;    Etn;    ethanolamine;    EtnP;    ethanolamine phosphate;    ChoP;    choline phosphate;    PtdEtn;    phosphatidylethanolamine;    PLD;    phospholipase D;    PLC;    phospholipase C;    DMBA;    7;    12-dimethylbenz[a]anthracene;    B[a]P;    benzo[a]pyrene;   

DOI  :  10.1016/0014-5793(93)81622-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Many human tumors contain high concentrations of ethanolamine phosphate (EtnP). An important question is whether increased formation of EtnP is merely the consequence of cell transformation, or is it associated with the process of carcinogenesis. Here we show that in C₃H/10Tl/2 embryonic fibroblasts, an established cellular model for the study of carcinogenesis, the environmental carcinogens, 7,12-dimethylbenz[a]anthracene (DMBA) and benzo[a]pyrene (B[a]P) (0.1–1 concentration; 24 h treatment), stimulate phosphorylation of ethanolamine derived from increased hydrolysis of phosphatidylethanolamine. The results suggest that increased formation of EtnP is associated with the early stages of carcinogenesis. This observation may have prognostic value.

【 授权许可】

Unknown