Region‐specific expression of multiple lactase‐phlorizin hydrolase genes in intestine of rabbit

FEBS Letters

Mantei, Ned¹  Gächter, Thomas¹  Villa, Marco¹  Semenza, Giorgio¹  Boll, Werner¹  Brunschwiler, Django¹ 

[1] Department of Biochemistry, Swiss Federal Institute of Technology, ETH-Zentrum, CH-8092 Zürich, Switzerland

关键词: LPH;    lactase-phlorizin hydrolase;   

DOI  :  10.1016/0014-5793(93)81611-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have identified a total of 4 sequences coding for lactase-phlorizin hydrolase (LPH) in the rabbit. Individual rabbits each yielded three different LPH cDNA sequences, or three chromosomal segments containing exon 1 of the LPH gene, representing either three genes or allelic variants of two genes. The three sequences were found in differing proportions in intestinal mRNA depending on the position along the small intestine from which the RNA was isolated. If all these mRNAs are translated, posttranslational mechanisms previously implicated in the regulation of LPH in the rabbit will be acting on different enzyme species in different parts of the intestine. However, we find no evidence for more than one LPH gene in the rat, and have previously shown that humans have only one LPH gene. p]Lactase-phlorizin hydrolase; Developmental regulation; Small intestine; Gene family

【 授权许可】

Unknown