Induction of stathmin mRNA during liver regeneration

FEBS Letters

Peterson, Christine¹  Mori, Nozomu¹  Okazaki, Takashi¹  Himi, Toshiyuki¹ 

[1] Division of Neurogerontology, Andrus Gerontology Center, University of Southern California, Los Angeles, CA 90089-0191, USA

关键词: Hepatic growth;    Proliferation;    In situ hybridization;    Gene expression;    Growth-associated protein;    p!9;    Oncoprotein 18;    Plasticity;   

DOI  :  10.1016/0014-5793(93)81598-T

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Stathmin is a 19 kDa phosphoprotein, and is proposed to play a role in signal transduction in response to various extracellular stimuli that promote cellular growth and/or differentiation. We examined stathmin mRNA expression during development and liver regeneration in mice. Stathmin mRNA expression declined during the post-natal period and was undetected in adult liver. 36 h after partial hepatectomy, stathmin mRNA was rapidly induced and remained at elevated levels for at least 10 days. In situ hybridization experiments confirmed that stathmin mRNA expression occurred in hepatocytes. These results indicate that the stathmin gene expression appears to be repressed during the post-natal liver development, and is de-repressed by liver regeneration, which suggests that stathmin may be a good molecular marker of liver plasticity.

【 授权许可】

Unknown