FEBS Letters | |
Suppression of neuronal potassium A‐current by arachidonic acid | |
Villarroel, Alvaro1  | |
[1] Howard Hughes Medical Institute, Department of Neurobiology and Behavior, SUNY at Stony Brook, Stony Brook, NY11794-5230, USA | |
关键词: A-current; M-current; Potassium current; Inhibition; Arachidonic acid; Sympathetic neuron; | |
DOI : 10.1016/0014-5793(93)80726-B | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The effect of arachidonic acid on the A current (I A) has been studied in dissociated bullfrog neurons under whole-cell voltage-damp conditions. Arachidonic acid reduced I A in a dose-dependent and reversible manner without a shift in the prepulse inactivation voltage-current relation. 1.75 μM inhibited i A by 50%, and higher concentrations caused a total suppression. In addition, arachidonic add increased the M-current (I M), a different potassium current that does not inactivate. Neither indomethacin nor nordihydroguaiaretic acid, cyclooxygenase and lipoxygenase inhibitors respectively, prevented I A reduction. In contrast, nordihydroguaiaretic acid prevented I M enhancement. Eicosatetraynoic acid, an arachidonic acid analog that cannot be metabolized, also reduced I A. These results suggest that arachidonic acid metabolism is not required to suppress I A
【 授权许可】
Unknown
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