Expression of glutathione S‐transferase P‐form in primary cultured rat liver parenchymal cells by coplanar polychlorinated biphenyl congeners is suppressed by protein kinase inhibitors and dexamethasone

FEBS Letters

Matsumoto, Michi¹  Suzuki, Kazuo T.¹  Aoki, Yasunobu¹ 

[1] National Institute for Environmental Studies, 16-2 Onogawa, Tsukuba, Ibaraki 305, Japan

关键词: Glutathione S-transferase P-form;    Coplanar polyehlorinated biphenyl;    Epidermal growth factor;    Liver parenchymal cell;    Protein kinase C;    AP-1;    EGF;    epidermal growth factor;    GAPDH;    glyceraldehyde-3-phosphate dehydrogenase;    GST-P;    glutathione S-transferase P-form (EC 2.5.1.18);    PCB;    polychlorinated biphenyl;    PenCB;    3;    4;    5;    3';    4'-penta-chlorinated biphenyl;    TGF-α;    transforming growth factor-α;    TPA;    12-O-tetradecanoylphorbol-13-acetate;    TRE;    TPA responsive element;    XRE;    xenobiotic responsive element;   

DOI  :  10.1016/0014-5793(93)80386-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Glutathione S-transferase P-form (GST-P, EC 2.5.1.18) mRNA was expressed by epidermal growth factor as well as by 3,4,5,3',4'-penta-chlorinated biphenyl (PenCB) in primary cultured rat liver parenchymal cells. The expression of GST-P was suppressed by inhibitors of protein kinase C and dexamethasone, an antagonist of AP-1 transcription factor activity, whereas expression of cytochrome P4501A2 by PenCB was not affected by these reagents. The AP-1 related transcription factor may be essential for the expression of GST-P by PenCB as also may be a protein kinase C type enzyme.

【 授权许可】

Unknown