Potassium regulates plasma testosterone and renal ornithine decarboxylase in mice

FEBS Letters

Peñafiel, Rafael²  Cremades, Asunción¹  Sánchez-Capelo, Amelia²  Fuentes, Teodomiro¹  Tejada, Francisco¹ 

[1] Departments of Pharmacology, Faculty of Medicine, University of Murcia, 30100 Murcia, Spain;Departments of Biochemistry and Molecular Biology, University of Murcia, 30100 Murcia, Spain

关键词: Potassium;    Testosterone;    Sexual dimorphism;    Ornithine decarboxylase;    Mouse kidney;   

DOI  :  10.1016/0014-5793(93)80369-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Potassium deficiency produced different effects in the kidney of male or female mice. While in female, potassium deficiency caused a marked renal hypertrophy with no significant changes in testosterone-regulated enzymes, such as ornithine decarboxylase and β-glucuronidase, in the male the same treatment provoked a marked fall of these enzymes owing to a dramatic decrease in plasma testosterone. Potassium replenishment restored plasma testosterone and renal enzymatic activities. These results show for the first time, that potassium modulates circulating testosterone and suggest that this cation could exert an important regulatory role in controlling androgen actions.

【 授权许可】

Unknown