Biosynthesis of vitamin B12

FEBS Letters

Ozaki, S.-I.¹  Spencer, J.B.¹  Roessner, C.A.¹  Stolowich, N.J.¹  Min, C.¹  Scott, A.I.¹ 

[1] Center for Biological NMR, Department of Chemistry, Texas A&M University, College Station, TX 77843-3255, USA

关键词: Biosynthesis;    Corrin;    Precorrins-3;    -3x;    -4;    13C-NMR;    Pseudomonas denitrificans;   

DOI  :  10.1016/0014-5793(93)80306-F

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the vitamin B₁₂ biosynthetic pathway the enzymes responsible for the conversion of precorrin-3 to precorrin-4 have been identified as the gene products of cobG and cobJ from Pseudomonas denitrificans. CobG catalyzes the oxidation of precorrin-3 to precorrin-3x (a hydroxy lactone) whereas CobJ is a SAM-dependent C-17 methyl transferase and is necessary for ring contraction. A mechanism for ring contraction is proposed.

【 授权许可】

Unknown