Peroxynitrite modification of low‐density lipoprotein leads to recognition by the macrophage scavenger receptor

FEBS Letters

Darley-Usmar, Victor²  Moncada, Salvador²  Graham, Annette²  O'Leary, Vanessa²  Kalyanaraman, Balaraman¹  Hogg, Neil¹ 

[1]Biophysics Research Institute, Medical College of Wisconsin, 8701 Watertown Plank Rd, Milwaukee, WI 53226, USA

[2]Wellcome Research Laboratories, Langley Court, South Eden Park Road, Beckenham, Kent BR3 3BS, UK

关键词: Macrophage;    Peroxynitrite;    Low-density lipoprotein;    Atherosclerosis;    LDL;    low density lipoprotein;    DTPA;    diethylenetriamine penta acetic acid;    PBS;    phosphate-buffered saline;    TBARS;    thiobarbituric acid reactive substances;    MDA;    malondialdehyde;    TNBS;    trinitrobenzene sulphonate;    PMA;    phorbol myristoyl acetate;    REM;    relative electrophoretic mobility;    BSA;    bovine serum albumin;   

DOI  :  10.1016/0014-5793(93)80269-Z

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Peroxynitrite is an oxidant which could be formed in the vasculature by the reaction of superoxide with nitric oxide. It is capable of modifying amino acid residues and of initiating lipid peroxidation. In the present study we have shown that peroxynitrite converts low density lipoprotein to a form recognized by the macrophage scavenger receptor and that this process is associated with modification of the protein and lipid, and with the oxidation of α-tocopherol to α-tocopherol quinone.

【 授权许可】

Unknown