Comparison of ubiquinol and cytochrome c terminal oxidases

FEBS Letters

Musser, Siegfried M.¹  Chan, Sunney I.¹  Stowell, Michael H.B.¹ 

[1] Arthur Amos Noyes Laboratory of Chemical Physics, 127-72, California Institute of Technology, Pasadena, CA 91125, USA

关键词: Ubiquinol oxidase;    Cytochrome oxidase;    Electron transfer;    Proton pumping;   

DOI  :  10.1016/0014-5793(93)80156-O

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

There have been numerous instances in the recent literature where the properties of ubiquinol and cytochrome c terminal oxidases are compared. Here we specifically examine the cytochrome bo ₃-type ubiquinol oxidase from Escherichia coli and the cytochrome aa ₃-type cytochrome c oxidases. A second redox-active copper site (Cu_A) is present only in the cytochrome c oxidases and the physiological electron donors for the two enzymes are different (ubiquinol-8 vs. ferrocytochrome c). In our opinion, these differences are significant and most likely indicate that distinct turnover mechanisms are operative in the two enzymes.

【 授权许可】

Unknown