MFH‐1, a new member of the fork head domain family, is expressed in developing mesenchyme

FEBS Letters

Tanaka, Kiyoji¹  Wanaka, Akio²  Miura, Naoyuki¹  Tohyama, Masaya² 

[1]Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamada-Oka, Japan

[2]Department of Anatomy and Neuroscience, Osaka University Medical School, 2-2 Yamada-Oka, Suita, Osaka 565, Japan

关键词: Brain;    Development;    Fork head domain;    Kidney;    Mesoderm;    Mesenchyme;    dpc;    days post-coitum;    HNF;    hepatocyte nuclear factor;    PAGE;    polyacrylamide gel electrophoresis;   

DOI  :  10.1016/0014-5793(93)81785-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have isolated a novel mouse gene, MFH-1 (mesenchyme fork head 1) that is related to the Drosophila fork head and rat HNF3 genes. MFH-1 encodes a distinct fork head domain that is classified into a distinct subfamily. A recombinant MFH-1 protein could bind to the HNF3 binding site. MFH-1 is expressed temporally in developing embryos, first in the non-notochordal mesoderm and later in areas of mesenchymal condensation in the trunk, head, and limbs. Our results suggest that MFH-1 might be involved in the formation of special mesenchymal tissues.

【 授权许可】

Unknown