Ion channels: molecular basis of ion selectivity

FEBS Letters

Imoto, Keiji¹ 

[1] Department of Medical Chemistry, Kyoto University Faculty of Medicine, Kyoto 606-01, Japan

关键词: Ion channel;    Ion selectivity;    Site-directed mutagenesis;    Functional expression;    AChR;    acetylcholine receptor;    AMPA;    α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid;    GluR;    glutamate receptor;    NMDA;    N-methyl-D-aspartic acid;   

DOI  :  10.1016/0014-5793(93)81422-V

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Recent mutagenesis studies of the ion channel proteins have allowed us to identify amino acid residues critical in determining ion selectivity. Ion selectivity of a channel can be altered even by single animo acid substitutions. Functional analyses of mutants largely support views in classical biophysics that the pore size and the fixed charges are major determinants of ion selectivity. For full understanding of the molecular mechanism of ion selectivity, elucidation of the tertiary structure of channel proteins remains essential.

【 授权许可】

Unknown