Sunlight‐induced mutagenicity of a common sunscreen ingredient

FEBS Letters

McHugh, Peter J¹  Cridland, Nigel A¹  McKenzie, Edward A¹  Knowland, John¹ 

[1] Department of Biochemistry, South Parks Road, Oxford, OX1 3QU, UK

关键词: Sunscreen;    Padimate-O;    Octyl dimethyl PABA;    Parsol 1789;    Mutagenesis;    Carcinogenesis;   

DOI  :  10.1016/0014-5793(93)80141-G

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have tested the mutagenicity of a UV-B sunscreen ingredient called Padimate-O or octyl dimethyl PABA, which, chemically speaking, is identical to an industrial chemical that generates free radicals when illuminated. It is harmless in the dark but mutagenic in sunlight, attacking DNA directly. A commercial sunscreen containing Padimate-O behaves in the same way. UV-A in sunlight also excites Padimate-O, although less than UV-B. Some related compounds, including a known carcinogen, behave similarly. As mutagens may be carcinogenic, our results suggest that some sunscreens could, while preventing sunburn, contribute to sunlight-related cancers.

【 授权许可】

Unknown