d‐α‐Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells

FEBS Letters

Palozza, P.¹  Özer, N.K.¹  Azzi, A.¹  Boscoboinik, D.¹ 

[1] Institut für Biochemie und Molekularbiologie der Universität Bern, Bern, Switzerland

关键词: Smooth muscle cell proliferation;    d-α-Tocopherol;    Arteriosclerosis;    Low density lipoprotein;    DMEM;    Dulbecco's modified Eagle's medium;    EGTA;    ethylene glycol-bis(gb-aminoethyl ether) tetraacetic acid;    FCS;    fetal calf serum;    HEPES;    N-[hydroxyethyl]piperazine-N-N′-[2-ethanesulfonic acid];    LDL;    low density lipoprotein;    LDLmod;    low density lipoprotein modified by malondialdehyde;    PBS;    phosphate-buttered saline;    PDGF;    platelet derived growth factor;    PKC;    protein kinase C;    PMA;    phorbol 12-myristate 13-acetate;    SMC;    A7r5;    rat vascular smooth muscle cells;   

DOI  :  10.1016/0014-5793(93)81592-N

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-α-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.

【 授权许可】

Unknown