期刊论文详细信息
FEBS Letters | |
d‐α‐Tocopherol inhibits low density lipoprotein induced proliferation and protein kinase C activity in vascular smooth muscle cells | |
Palozza, P.1  Özer, N.K.1  Azzi, A.1  Boscoboinik, D.1  | |
[1] Institut für Biochemie und Molekularbiologie der Universität Bern, Bern, Switzerland | |
关键词: Smooth muscle cell proliferation; d-α-Tocopherol; Arteriosclerosis; Low density lipoprotein; DMEM; Dulbecco's modified Eagle's medium; EGTA; ethylene glycol-bis(gb-aminoethyl ether) tetraacetic acid; FCS; fetal calf serum; HEPES; N-[hydroxyethyl]piperazine-N-N′-[2-ethanesulfonic acid]; LDL; low density lipoprotein; LDLmod; low density lipoprotein modified by malondialdehyde; PBS; phosphate-buttered saline; PDGF; platelet derived growth factor; PKC; protein kinase C; PMA; phorbol 12-myristate 13-acetate; SMC; A7r5; rat vascular smooth muscle cells; | |
DOI : 10.1016/0014-5793(93)81592-N | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Native and malondialdehyde modified low density lipoproteins have been shown to stimulate smooth muscle cell proliferation (A7r5) in vitro. The stimulation is associated with an increase of protein kinase C activity. d-α-Tocopherol, at physiological concentrations, has been found to inhibit both protein kinase C activity and cell proliferation.
【 授权许可】
Unknown
【 预 览 】
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