期刊论文详细信息
FEBS Letters | |
Structural modifications associated with the change in Ca2+ sensitivity on activation of m‐calpain | |
Crawford, Catherine1  Brown, Nicholas1  | |
[1] Laboratory of Molecular Biophysics, University of Oxford, The Rex Richards Building, South Parks Road, Oxford, 0X1 3QU, UK | |
关键词: Ca2+-dependent protease; Ca2+ sensitivity; Calpain activation; Autolysis; | |
DOI : 10.1016/0014-5793(93)81112-D | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Autolysis of the Ca2+-dependent cysteine protease m-calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca2+ sensitivity. The appearance of increased Ca2+ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.
【 授权许可】
Unknown
【 预 览 】
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