Structural modifications associated with the change in Ca2+ sensitivity on activation of m‐calpain

FEBS Letters

Crawford, Catherine¹  Brown, Nicholas¹ 

[1] Laboratory of Molecular Biophysics, University of Oxford, The Rex Richards Building, South Parks Road, Oxford, 0X1 3QU, UK

关键词: Ca2+-dependent protease;    Ca2+ sensitivity;    Calpain activation;    Autolysis;   

DOI  :  10.1016/0014-5793(93)81112-D

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Autolysis of the Ca²⁺-dependent cysteine protease m-calpain involves cleavage of the large (80 kDa) and small (30 kDa) subunits of the enzyme, and an increase in Ca²⁺ sensitivity. The appearance of increased Ca²⁺ sensitivity was found to correlate with the cleavage of the large subunit after residue 9.

【 授权许可】

Unknown