Inactivation of synovial fluid α1‐antitrypsin by exercise of the inflamed rheumatoid joint

FEBS Letters

Blake, David R.¹  Winyard, Paul G.¹  Zhang, Zhi¹  Chidwick, Keith¹  Farrell, Adrian J.¹ 

[1] The Inflammation Research Group, London Hospital Medical College, University of London, London El 2AD, UK

关键词: α11-Antitrypsin;    Rheumatoid arthritis;    Serpin;    Oxidation;    Reactive oxygen species;    Inflammation;    Hypoxie reperfusion;    α1AT;    α1-antitrypsin;    ROS;    reactive oxygen species;    RA;    rheumatoid arthritis;    SF;    synovial fluid;   

DOI  :  10.1016/0014-5793(93)80123-C

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

α₁-Antitrypsin (α₁AT) is known to be oxidised by reactive oxygen species both in vitro and in vivo, leading to its inactivation. We report here that synovial fluid (SF) α₁AT is inactivated during exercise of the knee-joints of rheumatoid arthritis (RA) patients. Sequential SF sampling from exercised RA patients showed a marked decrease in the mean activity of α₁AT after exercise with no change in the molecular forms of α₁AT. No such inactivation was found in the control (continuously resting) RA patients. We suggest that oxidation may contribute to α₁AT inactivation as a consequence of ‘hypoxic-reperfusion’ injury after exercise of the inflamed joint.

【 授权许可】

Unknown